zebrafish models of human disease

'It is not birth, marriage or death, but gastrulation which is truly the most important time in your life', said lewis wolpert. 

In fact, inside the womb, the embryo traverses an obstacle course, an obstacle course to being...

current research interests

Human neurodevelopmental disorders range from devastating to disabling. Learning more about them is imperative for us to help prevent, manage and alleviate the suffering. However, dissecting the mechanism is challenging in the human system. Models of these diseases in the zebrafish offer a window to peer deeply into the molecular and cellular defects that manifest as phenotypes. 

We are interested in two classes of neurodevelopmental disorders. Mendelian disorders, that are caused by single gene mutations that are usually highly penetrant such as CHARGE Syndrome and Rubinstein Taybi Syndrome. Complex disorders, that result from interplay of multiple variations or mutations in the genome such as Specific Learning Disorders (Dyslexia, Dyscalculia, Dysgraphia), ADHD and Autism Spectrum Disorders.

Using zebrafish models of these diseases we aim to dig deeper into the brain pathologies. This means:

-Using genetic manipulations such as transgenics, antisense knockdowns and CRISPR-based mutations to perturb gene functions.

-Looking at neuronal and glial abnormalities in the brain

-Figuring out why the structural changes happened and what these changes do in the brain

-Creating behavioural correlates to assess the role of candidate genes

Zebrafish models of human diseases: our previous work

CHARGE syndrome 

Rubinstein Taybi Syndrome

Hereditary Hemochromatosis

Liver damage and Regeneration

Non-alcoholic Fatty liver disease

Contact Us

Chetana Sachidanandan PhD

CSIR-Institute of Genomics and Integrative Biology, CSIR-IGIB South Campus, Mathura Road, Near Sukhdev Vihar & CSIR-CRRI, New Delhi 110025, Phone: +91-11-29879-105, chetana@igib.in, chetana@igib.res.in