zebrafish models of human disease
'It is not birth, marriage or death, but gastrulation which is truly the most important time in your life', said lewis wolpert.
'It is not birth, marriage or death, but gastrulation which is truly the most important time in your life', said lewis wolpert.
current research interests
current research interests
Human neurodevelopmental disorders range from devastating to disabling. Learning more about them is imperative for us to help prevent, manage and alleviate the suffering. However, dissecting the mechanism is challenging in the human system. Models of these diseases in the zebrafish offer a window to peer deeply into the molecular and cellular defects that manifest as phenotypes.
Human neurodevelopmental disorders range from devastating to disabling. Learning more about them is imperative for us to help prevent, manage and alleviate the suffering. However, dissecting the mechanism is challenging in the human system. Models of these diseases in the zebrafish offer a window to peer deeply into the molecular and cellular defects that manifest as phenotypes.
We are interested in two classes of neurodevelopmental disorders. Mendelian disorders, that are caused by single gene mutations that are usually highly penetrant such as CHARGE Syndrome and Rubinstein Taybi Syndrome. Complex disorders, that result from interplay of multiple variations or mutations in the genome such as Specific Learning Disorders (Dyslexia, Dyscalculia, Dysgraphia), ADHD and Autism Spectrum Disorders.
We are interested in two classes of neurodevelopmental disorders. Mendelian disorders, that are caused by single gene mutations that are usually highly penetrant such as CHARGE Syndrome and Rubinstein Taybi Syndrome. Complex disorders, that result from interplay of multiple variations or mutations in the genome such as Specific Learning Disorders (Dyslexia, Dyscalculia, Dysgraphia), ADHD and Autism Spectrum Disorders.
Using zebrafish models of these diseases we aim to dig deeper into the brain pathologies. This means:
Using zebrafish models of these diseases we aim to dig deeper into the brain pathologies. This means:
-Using genetic manipulations such as transgenics, antisense knockdowns and CRISPR-based mutations to perturb gene functions.
-Using genetic manipulations such as transgenics, antisense knockdowns and CRISPR-based mutations to perturb gene functions.
-Looking at neuronal and glial abnormalities in the brain
-Looking at neuronal and glial abnormalities in the brain
-Figuring out why the structural changes happened and what these changes do in the brain
-Figuring out why the structural changes happened and what these changes do in the brain
-Creating behavioural correlates to assess the role of candidate genes
-Creating behavioural correlates to assess the role of candidate genes
Zebrafish models of human diseases: our previous work
Zebrafish models of human diseases: our previous work
CHARGE syndrome
CHARGE syndrome
Rubinstein Taybi Syndrome
Rubinstein Taybi Syndrome
Hereditary Hemochromatosis
Hereditary Hemochromatosis
Liver damage and Regeneration
Liver damage and Regeneration
Non-alcoholic Fatty liver disease
Non-alcoholic Fatty liver disease
Contact Us
Contact Us
Chetana Sachidanandan PhD
CSIR-Institute of Genomics and Integrative Biology, CSIR-IGIB South Campus, Mathura Road, Near Sukhdev Vihar & CSIR-CRRI, New Delhi 110025, Phone: +91-11-29879-105, chetana@igib.in, chetana@igib.res.in
