Zebrafish Chemical Genetics Lab
Cause for Celebration...
Congratulations to Zainab for her new paper on rescue of CHARGE-like phenotypes with small molecules!
Best wishes to Sandeep Basu for new adventures at the Harvard Medical School!
Zebrafish as a model for human diseases and for drug discovery
Small Molecule Inhibitors of NFkB Reverse Iron Overload and Hepcidin Deregulation in a Zebrafish Model for Hereditary Hemochromatosis Type 3. Basu et al. ACS Chemical Biology. 2018
Chemical and genetic rescue of an ep300 knockdown model for Rubinstein Taybi syndrome in zebrafish. Babu et al. BBA-Mol Basis of Disease. 2018
Rescue of neural crest-derived phenotypes in a zebrafish CHARGE model by Sox10 downregulation. Asad et al. Hum Mol Genet. 2016
Fishing out Bioactivities
Zebrafish development as assays to screen for toxicological properties of industrially important molecules e.g. Ionic Liquids
Teratogenic, cardiotoxic and hepatotoxic properties of related ionic liquids reveal the biological importance of anionic components. Pandey et al. RSC Advances. 2017
We use zebrafish screens in zebrafish to discover novel bioactives from the vast unexplored chemical space...
Identification of noreremophilane-based inhibitors of angiogenesis using zebrafish assays. Muthukumarasamy et al. Org Biomol Chem. 2016
Chetana Sachidanandan PhD
CSIR-Institute of Genomics and Integrative Biology, CSIR-IGIB South Campus, Mathura Road, Near Sukhdev Vihar & CSIR-CRRI, New Delhi 110025, Phone: +91-11-29879-105, firstname.lastname@example.org, email@example.com