THE Zebrafish Chemical Genetics Lab
current research interests
current research interests
Neurodevelopmental disorders are those that result from defects in brain development. These include conditions such as Specific Learning Disorders (SLD), Attention Deficit and Hyperactivity Disorder (ADHD), Autism Spectrum Disorders (ASD) and Intellectual Disability.
Neurodevelopmental disorders are those that result from defects in brain development. These include conditions such as Specific Learning Disorders (SLD), Attention Deficit and Hyperactivity Disorder (ADHD), Autism Spectrum Disorders (ASD) and Intellectual Disability.
Using zebrafish models of these diseases we aim to dig deeper into the brain pathologies. This means:
Using zebrafish models of these diseases we aim to dig deeper into the brain pathologies. This means:
-Using genetic manipulations such as transgenics, antisense knockdowns and CRISPR-based mutations to perturb gene functions.
-Using genetic manipulations such as transgenics, antisense knockdowns and CRISPR-based mutations to perturb gene functions.
-Looking at neuronal and glial abnormalities in the brain
-Looking at neuronal and glial abnormalities in the brain
-Figuring out why the structural changes happened and what these changes do in the brain
-Figuring out why the structural changes happened and what these changes do in the brain
-Creating behavioural correlates to assess the role of candidate genes
-Creating behavioural correlates to assess the role of candidate genes
Zebrafish models of human diseases
Zebrafish models of human diseases
CHARGE syndrome
CHARGE syndrome
Rubinstein Taybi Syndrome
Rubinstein Taybi Syndrome
Hereditary Hemochromatosis
Hereditary Hemochromatosis
Liver damage and Regeneration
Liver damage and Regeneration
Non-alcoholic Fatty liver disease
Non-alcoholic Fatty liver disease
Chemical biology in zebrafish
Chemical biology in zebrafish
Contact Us
Contact Us
Chetana Sachidanandan PhD
CSIR-Institute of Genomics and Integrative Biology, CSIR-IGIB South Campus, Mathura Road, Near Sukhdev Vihar & CSIR-CRRI, New Delhi 110025, Phone: +91-11-29879-105, chetana@igib.in, chetana@igib.res.in
