models of human disease
That we are born at all is pure magic! In fact, inside the womb, the embryo traverses an obstacle course, an obstacle course to being...
That we are born at all is pure magic! In fact, inside the womb, the embryo traverses an obstacle course, an obstacle course to being...
current research interests
current research interests
Human neurodevelopmental disorders range from devastating to disabling. Learning more about them is imperative for us to help prevent, diagnose, manage and alleviate the suffering. We are interested in two classes of neurodevelopmental disorders.
Human neurodevelopmental disorders range from devastating to disabling. Learning more about them is imperative for us to help prevent, diagnose, manage and alleviate the suffering. We are interested in two classes of neurodevelopmental disorders.
Mendelian disorders, that are caused by single gene mutations; usually highly penetrant and very rare e.g. Rubinstein Taybi Syndrome, Dravet Syndrome
Mendelian disorders, that are caused by single gene mutations; usually highly penetrant and very rare e.g. Rubinstein Taybi Syndrome, Dravet Syndrome
Complex disorders, that result from interplay of multiple variations or mutations in the genome, and are more common e.g. Specific Learning Disorders (Dyslexia, Dyscalculia, Dysgraphia), ADHD and Autism Spectrum Disorders.
Complex disorders, that result from interplay of multiple variations or mutations in the genome, and are more common e.g. Specific Learning Disorders (Dyslexia, Dyscalculia, Dysgraphia), ADHD and Autism Spectrum Disorders.
Using zebrafish models of these diseases we aim to dig deeper into the brain pathologies. This means:
Using zebrafish models of these diseases we aim to dig deeper into the brain pathologies. This means:
-Using genetic manipulations such as transgenics, antisense knockdowns and CRISPR-based mutations to perturb gene functions.
-Using genetic manipulations such as transgenics, antisense knockdowns and CRISPR-based mutations to perturb gene functions.
-Looking at neuronal and glial abnormalities in the brain
-Looking at neuronal and glial abnormalities in the brain
-Figuring out why the structural changes happened and what these changes do in the brain
-Figuring out why the structural changes happened and what these changes do in the brain
-Creating behavioural correlates to assess the role of candidate genes
-Creating behavioural correlates to assess the role of candidate genes
AUTISM SPECTRUM DISORDER
AUTISM SPECTRUM DISORDER
We are building a cohort of Autism Spectrum Disorder (ASD) patients. The patients samples will be subjected to genomic analysis to identify known and novel genetic changes that lead to ASD. Patient cells will also be used to create induced Pluripotent Stem Cells (iPSCs). These cells will be instrumental in investigating the role of the genes we identify in the neurodevelopmental program. More here.
We are building a cohort of Autism Spectrum Disorder (ASD) patients. The patients samples will be subjected to genomic analysis to identify known and novel genetic changes that lead to ASD. Patient cells will also be used to create induced Pluripotent Stem Cells (iPSCs). These cells will be instrumental in investigating the role of the genes we identify in the neurodevelopmental program. More here.
Zebrafish models of human diseases: our previous work
Zebrafish models of human diseases: our previous work
Rubinstein Taybi Syndrome
Rubinstein Taybi Syndrome
CHARGE syndrome
CHARGE syndrome
Hereditary Hemochromatosis
Hereditary Hemochromatosis
Liver damage and Regeneration
Liver damage and Regeneration
Non-alcoholic Fatty liver disease
Non-alcoholic Fatty liver disease
Contact Us
Contact Us
Chetana Sachidanandan PhD
CSIR-Institute of Genomics and Integrative Biology, CSIR-IGIB South Campus, Mathura Road, Near Sukhdev Vihar & CSIR-CRRI, New Delhi 110025, Phone: +91-11-29879-105, chetana@igib.in, chetana@igib.res.in
